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Pathogens
Antimicrobials
Involves source organ only
Mild-moderate infection
e.g., appendicitis or cholecystitis without perforation
Perforation without established infection
e.g., perforated peptic ulcer with source control within 24 hours
Extends beyond source organ
e.g., diverticulitis, perforated appendicitis, perforated peptic ulcer with delayed surgery >24 hours
Severe infection OR Health care-associated
e.g., post-operative abscess, anastomotic leak, peritonitis
Severe infection
Sepsis or septic shock
Oral Step-Down
Duration