Spectrum: Local Antimicrobial Stewardship, for Fraser Health

uIAI: Perforation without established infection

Duration

≤ 24 hours post-op

Empiric Regimen

Cefazolin 2 g IV q8h

AND

If gastric acid suppression or gastric malignancy:

Metronidazole 500 mg IV/PO q12h

Severe Beta-Lactam Allergy

Ciprofloxacin 400 mg IV q12h

OR

If hemodynamically stable, able to swallow, and functioning GI tract:

Ciprofloxacin 500 mg PO BID

AND

Metronidazole 500 mg IV/PO q12h