Low
Excellent
With prolonged therapy (>6wks) or if symptoms develop assess for peripheral/optic neuropathy
GI symptoms common- especially nausea/vomiting and metallic taste
Peripheral/optic neuropathy with extended therapy
Disulfiram-like reaction with alcohol (severe vomiting)
Rare neurotoxicity including aseptic meningitis and encephalopathy
Ethanol- disulfiram-like reaction
Increases levels of cyclosporine, lithium, warfarin, and phenobarbital and phenytoin
