Spectrum: Local Antimicrobial Stewardship, for UCLA Health

Empiric Treatment

Recommended Regimens

Pip/Tazo 3.375 g IV bolus f/b 3.375g IV q8h infused over 4 hours

OR

Cefepime 2 g IV q8h

OR

Meropenem 1-2 g IV q8

CONSIDER ADDING TO EACH OF THE ABOVE

Vancomycin (Dosing per pharmacy)

AND/OR

Gentamicin (Dosing per pharmacy)

Severe Beta-Lactam Allergy

Vancomycin (Dosing per pharmacy)

PLUS

Aztreonam 2 g IV q8h

OR

Ciprofloxacin 400 mg IV q8h

WITH OR WITHOUT

Gentamicin (Dosing per pharmacy)

Risk Factors for MRSA

  • Central venous catheter in place

  • Other indwelling hardware

  • Known colonization with MRSA

  • Recent (within 3 mos) or current prolonged hospitalization > 2 weeks

  • Transfer from a nursing home or subacute facility

  • Injection drug use

  • Hemodialysis dependent patients