Spectrum: Local Antimicrobial Stewardship, for UCLA Health

Cefepime

Restricted
Restricted

C. diff Risk

High

Oral Bioavailability

NA

Approximate Cost

$$

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Adult

1-2g IV q8-12h

Renal - Adult

Pediatric

Restricted Use

Suspected or documented Pseudomonas aeruginosa infection and in the management of gram-negative meningitis.

General Information

Common Usage

Common Usage

Broad spectrum antimicrobial with gram positive and gram negative coverage including Pseudomonas.

Used especially nosocomial infections involving resistant organisms

Drug Monitoring

Drug Monitoring

Laboratory

  • CBC, CMP weekly

Clinical

  • Hypersensitivity

  • Diarrhea

  • Other GI effects

Adverse Effects

Adverse Effects

  • GI effects

  • Hypersensitivity reactions

  • C. difficile

Additional Information

Additional Information

Higher dosing may be required for cystic fibrosis and/or febrile neutropenia

Pharmacology

Pharmacology

Antimicrobial class: 4th generation Cephalosporin

Pregnancy category: B

Average serum half life: 2 hours

Biliary penetration: Moderate

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic