Spectrum: Local Antimicrobial Stewardship, for UCLA Health

Aztreonam

Restricted
Restricted

C. diff Risk

Medium

Oral Bioavailability

NA

Approximate Cost

$$$$

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

Dosing

Adult

2g IV q8h for severe infections

Renal - Adult

Pediatric

CrCl > 30 mL/min/1.73m²- 30 mg/kg/dose IV Q8H

  • Max daily dose: 120 mg/kg/day or 8g/day

Continuous renal replacement therapy (CRRT)No adjustment necessary

Peritoneal Dialysis7.5-10 mg/kg/dose Q12H

Hemodialysis7.5-10 mg/kg/dose Q12H after hemodialysis on dialysis days

CrCl < 10 mL/min/1.73m²7.5-10 mg/kg/dose Q12H

CrCl 10-29 mL/min/1.73m²15-20 mg/kg/dose Q12H

Restricted Use

Aerobic gram-negative infections in beta-lactam allergic patients.

General Information

Common Usage

Common Usage

Therapy of gram negative infections including Pseudomonas, particularly in patients with penicillin and cephalosporin allergy or when there is no alternative susceptible agent

Nebulized form used in cystic fibrosis patients (Cayston)

Empiric therapy for febrile neutropenia with severe penicillin allergy when combined with additional Gram positive agent

Drug Monitoring

Drug Monitoring

Laboratory

  • Cr weekly (for dose-adjustment assessment)

Clinical

  • Hypersensitivity

  • Diarrhea

Adverse Effects

Adverse Effects

  • GI effects

  • Hypersensitivity

Additional Information

Additional Information

Has no Gram positive or anaerobic coverage

Pharmacology

Pharmacology

Antimicrobial class: Monobactam

Pregnancy category: B

Average serum half life: 2 hours

Biliary penetration: Moderate

Lung penetration: Therapeutic

Urine penetration: Therapeutic