Spectrum: Local Antimicrobial Stewardship, for Billings Clinic

Sinusitis - Adult

First Line Treatment

Amoxicillin-Clavulanate
875 mg q12h PO x 5-7 days

Risk for Antibiotic Resistance or Failed Initial Therapy

Risk Factors for Antibiotic Resistance

  • <2 yo or > 65yo

  • Daycare

  • Immunocompromised

  • Antibiotics within the past 30 days

  • Hospitalization in the past 5 days

  • Severe infection

Amoxicillin-Clavulanate XR 2000 mg PO q12h X 5-7 days

Beta-Lactam Allergy: Type I Hypersensitivity

Doxycycline 100 mg q12h X 5-7 days

OR

Levofloxacin 500-750 mg daily X 5-7 days (reserved for patients with no alternative options)