Spectrum: Local Antimicrobial Stewardship, for Billings Clinic

Doxycycline

C. diff Risk

Low

Oral Bioavailability

Excellent

Approximate Cost

PO: <$1/day
IV: ~$35/day

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Adult

100mg PO BID

100 mg IV BID - Excellent bioavailability - oral preferred if possible

General Information

Common Usage

Common Usage

  • Skin and soft tissue infection

  • Community acquired pneumonia

  • Malaria prophylaxis

  • Zoonoses

  • Methicillin resistant staphylococcus aureus infections

Adverse Effects

Adverse Effects

  • GI upset and erosive esophagitis

  • Photosensitivity rash

  • Teeth staining

Major Interactions

Major Interactions

  • Divalent cations - decreased absorption

  • Increased digoxin levels

  • Increased INR with warfarin

  • Some anticonvulsants can decrease doxycycline levels

Pharmacology

Pharmacology

Antimicrobial class: Tetracycline

Pregnancy category: D

Average serum half life: 18 hours

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Poor

Biliary penetration: Therapeutic

No renal adjustment required