Spectrum: Local Antimicrobial Stewardship, for Billings Clinic

Amoxicillin-Clavulanate

C. diff Risk

Medium

Oral Bioavailability

Moderate

Approximate Cost

$0.50-$2.00/day

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

Dosing

Renal

Pediatric

Adult

General Information

Common Usage

Common Usage

Prophylaxis/treatment of bite wounds.

Polymicrobial infections of the respiratory tract or abdomen.

Skin and soft tissue infections.

Drug Monitoring

Drug Monitoring

For prolonged therapy, monitor liver enzymes and renal function.

Adverse Effects

Adverse Effects

  •  Allergy/rash (immediate or delayed)

  •  Note EBV related rash

  •  Cytopenias

  •  Diarrhea

  •  Hepatotoxicity due to clavulinate - usually mild, liver failure is rare.

Major Interactions

Major Interactions

Increased risk of rash with allopurinol

Additional Information

Additional Information

For Streptococcus pneumoniae infections use amoxicillin, NOT amoxicillin-clavulanate as the clavulanate does not add anything other than side effects in this setting.

Pharmacology

Pharmacology

Antimicrobial class: Aminopenicillin + Beta-lactamase inhibitor

Pregnancy category: B

Average serum half life: 1 hour

Biliary penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic