Spectrum: Local Antimicrobial Stewardship, for Billings Clinic

Streptococcus pyogenes

Moderate/Severe Treatment

Penicillin G 3-4 million units IV every 4 hours

OR

Ampicillin 2 g IV every 4-6 hours

OR

Cefazolin 2 g IV every 8 hours

PLUS (for severe/toxin production)

Clindamycin 600-900 mg IV every 8 hours

Clindamycin may be removed once toxin production has subsided