Spectrum: Local Antimicrobial Stewardship, for Billings Clinic

Penicillin G (IV)

C. diff Risk

Low

Oral Bioavailability

NA

Approximate Cost

$20-30/day

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Renal

Adult

18-24 million units/day IV in 6 divided doses or continuous infusion

Common doses are 3-4 million units IV q4h

General Information

Common Usage

Common Usage

  •  Therapy of Streptococcal and other documented susceptible infections

  •  Neurosyphilis

First Line Indications

First Line Indications

Neurosyphilis

Adverse Effects

Adverse Effects

  • Allergy/rash (immediate or delayed)

  • Seizures

  • Cytopenias

  • Eosinophilia

  • Interstitial nephritis

  • Abnormal liver enzymes

  • Serum sickness

  • Syphilis treatment: Jarisch-Herxheimer reaction - an acute febrile reaction, often accompanied by headache, myalgia, and rash may occur with onset of treatment

Additional Information

Additional Information

Comes as potassium (formulary) or sodium (nonformulary) formulations. Monitor electrolytes as appropriate

Pharmacology

Pharmacology

Antimicrobial class: Penicillin

Pregnancy category: B

Average serum half life: 1 hour

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Moderate

Biliary penetration: Therapeutic