Spectrum: Local Antimicrobial Stewardship, for Billings Clinic

Ampicillin

C. diff Risk

Low

Oral Bioavailability

Low

Approximate Cost

See Below

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Renal

Pediatric

Adult

Low Dose (UTI)1-2 g q6h

High Dose (Endocarditis, Bacteremia)2 g q4h

General Information

Common Usage

Common Usage

Pathogen directed therapy for CNS, intravascular, intraabdominal, urinary and other infections especially Enterococcus and Listeria

Cost Dollar

Cost

IV: $10-15/day

PO: Nonformulary - prefer amoxicillin in most scenarios

Adverse Effects

Adverse Effects

Allergy and rash

EBV related rash (not allergy).

Rare: cytopenias, +ve Coombs.

Major Interactions

Major Interactions

Increased risk of rash with allopurinol.

Additional Information

Additional Information

Ampicillin susceptibility implies amoxicillin susceptibility.

Use amoxicillin for conversion to oral as appropriate. Oral amoxicillin has better bioavailability and less GI side effects than oral ampicillin.

Pharmacology

Pharmacology

Antimicrobial class: Aminopenicillin

Pregnancy category: B

Average serum half life: 1 hour

Biliary penetration: Therapeutic

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic