Spectrum: Local Antimicrobial Stewardship, for Billings Clinic

Cefazolin

C. diff Risk

Medium

Oral Bioavailability

NA

Approximate Cost

<$4/day

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Renal

Pediatric

100 to 150 mg/kg/day divided q8h

Adult

Standard dose: 2 g IV q8h

Obesity (>120 kg): 2 g IV q6h

General Information

Unacceptable Uses

Unacceptable Uses

Meningitis (does not penetrate the CSF)

Common Usage

Common Usage

  • Skin and soft tissue infection (e.g. nonpurulent cellulitis).

  • Surgical prophylaxis.

  • Susceptible Staphylococcal, Streptococcal and gram-negative infections.

Drug Monitoring

Drug Monitoring

Weekly BMP and CBC

Adverse Effects

Adverse Effects

Allergy (immediate or delayed).

Can cause positive Coombs, cytopenias, and hepatic and renal laboratory abnormalities.

Pharmacology

Pharmacology

Antimicrobial class: 1st Generation Cephalosporin

Pregnancy category: B

Average serum half life: 2 hours

Biliary penetration: Therapeutic

CSF penetration: Poor

Lung penetration: Therapeutic

Urine penetration: Therapeutic