Home
Guidelines
Pathogens
Antimicrobials
14 to 21 days
Transition from empiric to definitive therapy should occur once GBS is identified by culture; clinical improvement is evident and and for meningitis, only when CSF is sterile at 24 to 48 hours of therapy.
Ampicillin (See Dosing Below)
7 Days of Age
67 mg/kg IV q8h
More Than 7 Days of Age
75 mg/kg IV q6h
PLUS EITHER
Gentamicin (See Dosing Below)
PMA Less Than 34 Weeks 3 mg/kg IV q24h
PMA 34 Weeks or More 3 mg/kg IV q18h
1 kg or Less 3.5 mg/kg IV q24h
More Than 1 kg PMA Less Than 37 Weeks 2.5 mg/kg IV q12h
PMA 37 Weeks or More 2.5 mg/kg IV q8h
OR
Cefotaxime (See Dosing Below)
2 kg or Less 50 mg/kg IV/IM q12h
Over 2 kg 50 mg/kg IV/IM q8h-q12h
Less Than 1.2 kg 50 mg/kg IV/IM q12h
1.2 - 2 kg 50 mg/kg IV/IM q8h
Over 2 kg 50 mg/kg IV/IM q6h-q8h
Penicillin G (See Dosing Below)
80,000-150,000 units/kg IV/IM q8h
112,000 units/kg IV/IM q6h
