Spectrum: Local Antimicrobial Stewardship, for Markham Stouffville Hospital

Cefotaxime

C. diff Risk

High

Oral Bioavailability

NA

Approximate Cost

Reserved for Pediatrics

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

Dosing

Renal

CrCl Less Than 10 mL/min1-2 g q24h (or reduce usual dosing by 50%)

CrCl 10-24 mL/min1-2g q6-12h

CrCl 25-49 mL/min1-2g q6-12h

CrCl Greater Than 50 mL/min1-2 g q4-12h

Adult

1-2g IV q4-12h

General Information

Common Usage

Common Usage

Empiric therapy for:

  •  Bacterial meningitis

  •  Pneumonia (in combination with a macrolide)

  •  Intra-abdominal infection including SBP

  •  Musculoskeletal i.e. septic arthritis

  •  Urinary tract infection

Adverse Effects

Adverse Effects

  •  Rash

  •  Localized phlebitis at injection site

  •  Allergy

  •  Positive Coombs test

  •  Neutropenia

  •  Abnormalities in liver enzymes

  •  Diarrhea

  •  CDI

Additional Information

Additional Information

Reserved for use in Paediatrics.

Pharmacology

Pharmacology

Antimicrobial class: 3rd Generation Cephalosporin

Pregnancy category: B

Average serum half life: 1.5 hours

Biliary penetration: Moderate

CSF penetration: Therapeutic when inflamed meninges

Lung penetration: Therapeutic

Urine penetration: Therapeutic