Spectrum: Local Antimicrobial Stewardship, for Markham Stouffville Hospital

Ampicillin

C. diff Risk

Low

Oral Bioavailability

NA

Approximate Cost

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Renal

CrCl Less Than 10 mL/min1-2 g q12-24 h

CrCl 25-49 mL/min1-2 g q6-12h

CrCl Greater Than 50 mL/min1-2 g q4-6h

CrCl 10-24 mL/min1-2 g q6-12h

Adult

1-2g IV q4-6h

2g IV q4h for meningitis or endocarditis

General Information

Common Usage

Common Usage

Pathogen directed therapy for CNS, intravascular, intraabdominal, urinary and other infections especially Enterococcus and Listeria.

Adverse Effects

Adverse Effects

Allergy and rash as for all beta-lactams.

EBV related rash (not allergy).

Rare: cytopenias, +ve Coombs.

Major Interactions

Major Interactions

Increased risk of rash with allopurinol.

Pharmacology

Pharmacology

Antimicrobial class: Aminopenicillin

Pregnancy category: B

Average serum half life: 1 hour

Biliary penetration: Therapeutic

CSF penetration: Therapeutic with inflamed meninges

Lung penetration: Therapeutic

Urine penetration: Therapeutic