Early Syphilis

Clinical Manifestations

Typically consists of a single painless chancre at the site of inoculation, accompanied by regional adenopathy

A systematic illness that often includes a rash (disseminated and/or involving the palms and soles), fever, malaise, and other symptoms such as pharyngitis, hepatitis, mucous patches, condyloma lata, alopecia

Refers to the period when a patients is infected with Treponema pallidumas as demonstrated by serological testing, but has no symptoms. Early latent occurs within the 1st year of initial infection

Preferred Treatment

Penicillin G benzathine 2.4 million units IM x 1

Monitoring After Treatment

Clinical exam and serologic testing with a nontreponemal test (e.g. RPR) at 6 and 12 months

Titers should be checked more frequently if the patient is HIV infected, follow-up is uncertain, or reinfection is a concern