Spectrum: Local Antimicrobial Stewardship, for Bakersfield Memorial Hospital

Ceftriaxone

C. diff Risk

High

Oral Bioavailability

NA

Approximate Cost

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Adult

Usual Dose - 1-2 g IV every 24 hr

Bacterial meningitis - 2 g IV every 12 hr

Pediatric

General Information

Common Usage

Common Usage

Empiric therapy of:

  • Bacterial meningitis

  •  Nosocomial gram negative infections (except Pseudomonas)

  •  Spontaneous bacterial peritonitis

  •  Hospitalized community or nursing home acquired pneumonia in combination with a macrolide

Drug Monitoring

Drug Monitoring

Clinical

  • Hypersensitivity

  • Diarrhea

Adverse Effects

Adverse Effects

  •  Allergy/rash (immediate or delayed)

  •  Cytopenias

  •  Eosinophilia

  •  Hepatic & renal laboratory abnormalities

  •  Pseudocholelithiasis. Unclear clinical significance. Uncommonly symptomatic, but frequently by ultrasound gallbladder sludge

Pharmacology

Pharmacology

Antimicrobial class: Parenteral Cephalosporin - 3rd Generation

Pregnancy category: B

Average serum half life: 8 hours

Biliary penetration: Therapeutic

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic