Spectrum: Local Antimicrobial Stewardship, for Bakersfield Memorial Hospital

Doxycycline

C. diff Risk

Low

Oral Bioavailability

Excellent

Approximate Cost

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

Dosing

Adult

100 mg PO/IV every 12 hr

General Information

Unacceptable Uses

Unacceptable Uses

Avoid in pregnant women and children < 8 yr, permanent staining of developing teeth may occur.

Common Usage

Common Usage

  • Skin and soft tissue infection

  • Community acquired pneumonia

  • Malaria prophylaxis

  • Zoonoses

  • Methicillin resistant staphylococcus aureus infections

Drug Monitoring

Drug Monitoring

Lab

  • Consider periodic LFTs with prolonged use

Clinical

  • Hypersenistivity

  • GI effects/diahhrea

  • Photosensitivity

Adverse Effects

Adverse Effects

  • GI upset and erosive esophagitis

  • Photosensitivity rash

  • Teeth staining (avoid in pregnant women and children)

Major Interactions

Major Interactions

  • Divalent cations - decreased absorption

  • Increased digoxin levels

  • Increased INR with warfarin

  • Some anticonvulsants can decrease doxycycline levels

Pharmacology

Pharmacology

Antimicrobial class: Tetracycline

Pregnancy category: D

Average serum half life: 18 hours

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Poor

Biliary penetration: Therapeutic