Spectrum: Local Antimicrobial Stewardship, for Prisma Health Children’s Hospital-Midlands

≥ 96 hrs After Initation

Treatment

Anidulafungin

OR

Amphotericin B liposomal (Ambisome)

Concern For Invase Aspergillus?

Note

  • Perform serum galactomannan and B-D-Glucan test

  • Perform chest computed tomographic (CT) scan, regardless of chest radiographic results

Yes

No

High Risk for Invasive Fungal Disease

  • AML

  • Relapsed acute leukemia

  • Receiving highly myelosuppressive chemotherapy for other malignancies with persistent fever despite prolonged (>96 hrs) broad spectrum antibiotics and expected prolonged neutropenia (>10 days)