Low
NA
$$$$$$
Fungicidal therapy of yeast/fungus/mold infection (not for use in urinary tract infection)
Invasive candidiasis, aspergillosis, cryptococcosis
Visceral/mucocutaneous Leishmaniasis
Induction therapy for dimorphic fungii (cocci, blasto, histo)
Renal function, fluid status, serum electrolytes (K, Mg)
Liver enzymes, CBC with differential
Infusion related symptoms: fever/rigors/N/V/headache
Electrolyte abnormalities - hypokalemia and hypomagnesemia, loss of bicarb
Nephrotoxicity ++
Anemia
Phlebitis
Paresthesias
Enhance nephrotoxic effect with concomitant use of other nephrotoxins - use should be minimized during amphotericin therapy
*ASP approval required. Pre-approved if following a CH treatment pathway
*Lipid formulations of AmB (Ambisome, Abelcet) are NOT interchangable
Premedication with acetaminophen, diphenhydramine, or hydrocortisone for infusion related symptoms
Antimicrobial class: Antifungal - polyene - Lipid formulations (designed to minimize toxicity)
Average serum half life:
No pediatric data
Liposomal: Adults: 100-153 hours (terminal half life)
Lipid Complex: Adults: 173 hours (terminal half life)
Route of Elimination: Lipid Complex: 0.9% of drug excreted in urine over 24h; effects of hepatic and renal impairment on drug disposition are unknown.
