Spectrum: Local Antimicrobial Stewardship, for Prisma Health Children’s Hospital-Midlands

Human Bite

Common Pathogens

Streptococci

S. aureus

Eikenella

Anaerobes

Recommendation

Update tetanus vaccine if necessary

Recommended Empiric Treatment

Amoxicillin/Clavulanate (Augmentin®) PO

OR

Ampicillin/sulbactam (Unasyn®) IV

If not tolerating PO

Alternative Regimens

Levofloxacin PO

AND

Clindamycin PO

OR

Ceftriaxone IV

AND

Metronidazole IV

De-escalation

De-escalate to narrowest spectrum PO antibiotic based on susceptibilities

Duration

5 days