Spectrum: Local Antimicrobial Stewardship, for Prisma Health Children’s Hospital-Midlands

Clindamycin

C. diff Risk

High

Oral Bioavailability

Good (70 to 90%)

Approximate Cost

IV$$$ PO$$

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Pediatric

Neonatal

General Information

Common Usage

Common Usage

Gram positive skin and soft tissue infections including necrotizing fasciitis as an adjunctive agent to a beta lactam for reducing toxin production

Skin & soft tissue infections involving susceptible MRSA

Susceptible infections and surgical prophylaxis in setting of IgE mediated beta-lactam allergy

For decreasing toxin production in toxic shock syndrome

Drug Monitoring

Drug Monitoring

Monitor for diarrhea, CBC, hepatic & renal function

If severe diarrhea, consider C. diff infection

Adverse Effects

Adverse Effects

  • Allergy (immediate & delayed)

  • GI upset

  • Diarrhea

  • Cytopenia

  • Abnormal liver enzymes

  • Pseudomembranous colitis.

Pharmacology

Pharmacology

Antimicrobial class: Lincosamide

Average serum half life:

  • Premature neonates: 8.7 hours

  • Full term neonates: 3.6 hours.

  • Infants 1 month to 1 year: 3 hours.

  • Children and Adults: 2-3 hours

Biliary Penetration: High

Route of Elimination: Mostly hepatic metabolism. 10% of an oral dose excreted in urine and 4% excreted in feces as active drug and metabolites