Medium
Good (70 to 90%)
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Renally cleared, requires dosage adjustment with changes in renal function. Consult a pharmacist for renal dosing.
Use with caution. Use contraindicated in patients with a history of amoxicillin and clavulanate-associated hepatic dysfunction.
For high dose, to keep clavulanic acid dose < 12.5 mg/kg/DAY, 14:1 formulation (90mg/kg/DAY) can be achieved by combining 45mg/kg/DAY of 7:1 formulation & 45mg/kg/DAY of plain amoxicillin.
Prophylaxis/treatment of bite wounds
Polymicrobial infections of the respiratory tract or abdomen
Diarrhea (common)
Allergy/rash, cytopenias
Hepatotoxicity due to clavulinate is usually mild, liver failure is rare
EBV related rash (not allergy)
Antimicrobial class: Aminopenicillin + Beta-lactamase inhibitor
Average serum half life: Adults: ~1 hour. Amoxicillin pharmacokinetics are not affected by clavulanic acid
Biliary Penetration: Good
Route of Elimination: Urine (amoxicillin 50% to 70% unchanged drug; clavulanic acid 25% to 40% unchanged drug)
