Fulminant CDI | Spectrum

Contact Precautions Plus

Institute contact precautions plus for any suspected or confirmed CDI case

Duration of Therapy

10 days

Patients with delayed response may require up to 14 days

Consult

Consider Infectious Diseases, General Surgery, and ICU consultation

Empiric Therapy

Vancomycin 500 mg PO/NG QID

AND

MetroNIDAZOLE 500 mg IV Q8H

AND

If ileus present, consider ADDING:

Vancomycin 500 mg in 100 mL normal saline Q6H as retention enema

Note

Probiotics (i.e. Lactobacillus) or cholestyramine are NOT recommended as adjunctive treatment for or prevention of recurrent CDI as evidence regarding their efficacy is unclear.

Infectious Diseases consultation should be considered for patients who have other infections requiring concomitant antibiotics in setting of C. difficile infection