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Antimicrobials
Contact Precautions Plus
Institute contact precautions plus for any suspected or confirmed CDI case
10 days
Vancomycin 125 mg PO/NG QID
For non-severe CDI only (e.g., WBC less than 15 and creatinine less than 133):
MetroNIDAZOLE 500 mg PO/NG TID
Probiotics (i.e. Lactobacillus) or cholestyramine are NOT recommended as adjunctive treatment for or prevention of recurrent CDI as evidence regarding their efficacy is unclear.
Infectious Diseases consultation should be considered for patients who have other infections requiring concomitant antibiotics in setting of C. difficile infection