Spectrum: Local Antimicrobial Stewardship, for Fraser Health

Severe HAP

Duration

7 days

Empiric Treatment

Piperacillin-tazobactam 4.5 g IV q6h

AND

Vancomycin

AND

If septic shock or needing ventilatory support, consider adding 2nd anti-pseudomonal agent from a different class:

Tobramycin 7 mg/kg IV q24h

OR

Ciprofloxacin 400 mg IV q8h

Severe Beta-lactam Allergy

Meropenem 500 mg IV q6h

OR

Levofloxacin 750 mg PO q24h

AND

Vancomycin

AND

If septic shock or needing ventilatory support, consider adding 2nd anti-pseudomonal agent from a different class:

Tobramycin 7 mg/kg IV q24h

OR

Ciprofloxacin 400 mg IV q8h