Levofloxacin

General Information

Monitor QTc in patients with increased risk

QTc prolongation

Dysglycemia

CNS toxicity including confusion, psychosis

Tendinopathy and rupture

GI upset

Weakness exacerbation in myasthenia gravis

Rash

Other QTc prolonging agents

Di- & Trivalent cations including Al, Ca, Fe, Mg (antacids, dairy products, iron supplements, some enteral feeds) - decreased absorption

NSAIDs - increase seizure risk

Warfarin - increased INR

May exacerbate muscle weakness in persons with myasthenia gravis. Avoid Use.

Antimicrobial class: Fluoroquinolone

Pregnancy category: C