Greater than 37 Weeks

Most Likely Pathogen

Group B Streptococcus

Until delivery

Ideally initiate more than 4 hours prior to delivery

Penicillin G 5 million units IV once, then 2.5 million units IV q4h

Cefazolin 1-2 grams IV q8h

OR

If GBS is sensitive/susceptible (40 % resistance):
Clindamycin 600-900 mg IV q8h

OR

Vancomycin 15-20 mg/kg/dose IV q8-12h