High
Excellent
IV-$18/d PO-$2/d
Anaerobic infections above the diaphragm, especially dental infection.
Gram positive skin and soft tissue infections including necrotizing fasciitis as an adjunctive agent to a beta lactam for reducing toxin production.
Skin and soft tissue infections involving susceptible MRSA.
Susceptible infections and surgical prophylaxis in setting of IgE mediated beta-lactam allergy.
For decreasing toxin production in toxic shock syndrome.
Monitor for:
Diarrhea -if severe diarrhea, consider C.diff infection
CBC
Hepatic Function
Renal function
Allergy (immediate & delayed)
GI upset, diarrhea, pseudomembranous colitis
Cytopenia
Abnormal liver enzymes
Concentration: 15 mg/mL
Taste: less palatable, unpleasant taste
Not all strengths of oral liquids are listed nor are available on IWK formulary
150 mg capsule
Tablets and capsules are preferred especially over an unpleasant tasting liquid.
Not all strengths of oral tablets/capsules are listed and they are not all available on the IWK formulary.
Some preparations of Clindamycin injection contain benzyl alcohol, which has caused gasping syndrome in neonates.
Antimicrobial class: Lincosamide
Average serum half life:
Premature neonates: 8.7 hours
Full term neonates: 3.6 hours.
Infants 1 month to 1 year: 3 hours.
Children and Adults: 2-3 hours
Route of Elimination: Mostly hepatic metabolism. 10% of an oral dose excreted in urine and 3.6% excreted in feces as active drug and metabolites.
