Gram positive: Methicillin Susceptible Staphylococcus aureus (MSSA) and susceptible Methicillin Resistant Staphylococcus aureus (MRSA) , most streptococci (but increasing resistance with Group B streptococcus ), viridans streptococci

Anaerobes: Increasing resistance in Bacteroides fragilis; covers many oral anaerobes

Other: Pneumocyctis jiroveci, malaria, toxoplasmosis

Does not cover: almost all aerobic gram negatives, enterococci.