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Guidelines
Pathogens
Antimicrobials
In severely ill patients with cholangitis or complicated cholelithiasis, adequate biliary drainage is crucial as antibiotics will not enter bile in the presence of obstruction.
CT scan is important in assessing need for drainage in severe disease.
Some patients will present with diffuse peritonitis.
Pip/tazo 3.375 g IV q8h over 4 hours
Ciprofloxacin 400 mg IV q12h
PLUS
Metronidazole 500 mg IV q8h
Complicated Cholecystitis
5-10 days.
Trend is now favoring shorter regimens
Biliary Sepsis
5-14 days.
Shorter course favored if source controlled.
Average duration is 7 days.