Spectrum: Local Antimicrobial Stewardship, for UCLA Health

Neurosurgery or Head Trauma

Most Likely Pathogens

S. pneumo (if CSF leak)

H. influenzae

Staphylococci (MRSA, CoNS)

Gram-negatives

Preferred Regimen

Vancomycin (Dosing per pharmacy)

PLUS EITHER

Cefepime 2 g q8h

OR

Meropenem 2g q8h

Penicillin Anaphylaxis

ID consult advised

Vancomycin (Dosing per pharmacy)

PLUS

Meropenem 2g q8h

Duration