Spectrum: Local Antimicrobial Stewardship, for UCLA Health

Acute cystitis

Definitions

Acute cystitis

Signs and symptoms (e.g. dysuria, urgency, frequency, suprapubic pain) AND pyuria (>5-10 WBC/hpf) AND positive urine culture ≥ 100,000 colonies.

Uncomplicated

  •  Female

  • No urologic abnormalities

  • No stones

  • No catheter

Complicated

  •  Male

  • Stones

  • Urologic abnormality

  • Pregnancy

Initial Empiric Treatment - Uncomplicated

TMP/SMX 1 DS PO q12H x 3 days

OR

Cephalexin 500 mg PO q6H x 7 days

OR

Nitrofurantoin 100 mg PO q12H x 5 days*

*Do NOT use in patients with CrCl < 40 ml/min

Initial Empiric Treatment - Complicated

Same regimens as above, except duration is 7-14 days.

For pregnant patients, review pregnancy category and trimester of patient prior to prescribing