Spectrum: Local Antimicrobial Stewardship, for Markham Stouffville Hospital

Penetrating Trauma

Common Pathogens

Staphyloccocus aureus

MRSA Risk Factors:

  • Evidence of MRSA infection elsewhere

  • Nasal colonization with MRSA

  • Injection drug use

GAS

Gram negative organisms

Including Pseudomonas aeruginosa

Empiric IV Antimicrobial Regimen

Piperacillin-tazobactam 4.5g IV Q6H

If MRSA Risk Factors Present

ADD

Vancomycin (Dosing Below)

Adults

Vancomycin 15-20mg/kg Q8-12H

Pediatrics

Birth to 3 Months
Vancomycin 15mg/kg IV Q6H

Over 3 Months
Vancomycin 10mg/kg IV Q6H