Haemophilus influenza type b (Infants and Children)

Duration of Therapy

7 Days

If β-lactamase Positive

Greater than 1 month of age
100 mg/kg IV at 0, 12, and 24 h followed by 100 mg/kg IV q24h or 50 mg/kg IV q12h

Dose limit: 4 g/day (2 g/dose)

If β-lactamase Negative

50-100 mg/kg IV q6h

Dose limit: 12 g/day (3 g/dose)

OR

Greater than 1 month of age
100 mg/kg IV at 0, 12, and 24 h followed by 100 mg/kg IV q24h or 50 mg/kg IV q12h

Dose limit: 4 g/day (2 g/dose)

Penicillin/Beta-lactam Allergy

If the patient has a true history of IgE mediated penicillin allergy, the risks versus benefit of empiric treatment of suspected meningitis with appropriate antimicrobials should be discussed.