Spectrum: Local Antimicrobial Stewardship, for Markham Stouffville Hospital

CefTRIAXone

C. diff Risk

High

Oral Bioavailability

NA

Approximate Cost

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Renal

No adjustment required

Adult

Usual Dose 1-2 g IV q24h

Bacterial meningitis 2 g IV q12h

General Information

Common Usage

Common Usage

Empiric therapy of:

  • Bacterial meningitis

  • Endocarditis

  • Intra-abdominal Infections

  •  Nosocomial gram negative infections (except Pseudomonas)

  • Pneumonia

  •  Spontaneous bacterial peritonitis

  • Skin, bone/joint and soft tissue infections

  • Urinary Tract Infections

Adverse Effects

Adverse Effects

  •  Allergy/rash (immediate or delayed)

  •  Cytopenias

  •  Eosinophilia

  • GI disturbances (including diarrhea)

  •  Hepatic & renal laboratory abnormalities

  •  Pseudocholelithiasis (unclear clinical significance, commonly asymptomatic)

Pharmacology

Pharmacology

Antimicrobial class: Parenteral Cephalosporin - 3rd Generation

Pregnancy category: B

Average serum half life: 8 hours

Biliary penetration: Therapeutic

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic