Late Syphilis

Clinical Manifestations

Patients with late syphilis who have symptomatic manifestations involving the cardiovascular system or gummatous disease (granulomatous disease of the skin and subcutaneous tissues, bones or viscera)

The period when a patient is infected with Treponema pallidumas as demonstrated by serological testing, but as no late symptoms. Late latent syphilis occurs more than one year after initial infection. If the timing of the infection is unknown, late latent syphilis is presumed

Preferred Treatment

Penicillin G benzathine 2.4 million units IM once weekly for 3 weeks

Monitoring After Treatment

Clinical exam and serologic testing with a nontreponemal test (e.g. RPR) at 6, 12 and 24 months