Spectrum: Local Antimicrobial Stewardship, for Eastern Health

NVE Tx MSSA

Duration of Therapy

SIX weeks for left sided and complicated right sided IE

Shorter durations acceptable for uncomplicated right sided MSSA IE - discuss with ID

The course starts from the first negative blood culture, and may require alteration if complications occur or the patient requires surgery/valve replacement

Suggested Regimen

Cloxacillin 2g IV q4H

Non-Anaphylactic Penicillin Allergy

Cefazolin 2g IV q8h

Penicillin Anaphylaxis

Vancomycin IV loading dose followed by maintenance for target trough of 15-20 ug/mL
see dosing nomogram

If patient cannot be dosed using nomogram
contact Pharmacy.

Review nature of allergy and consider desensitization procedure for a penicillin/cephalosporin (optimal therapy)

Desensitization procedure

Drug to which patient has an immediate hypersensitivity reaction, is administered in increasing increments to allow TEMPORARY tolerance of the drug for a period of required therapy.