Spectrum: Local Antimicrobial Stewardship, for Eastern Health

Cloxacillin

C. diff Risk

Medium

Oral Bioavailability

Moderate (40 to 70%)

Approximate Cost

$1.08 (PO)
$15.00 (IV)

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

Dosing

Renal

No dosage adjustment required for renal dysfunction

Adult

2g IV q4-6h

500-1000 mg PO q6h

General Information

Common Usage

Common Usage

Treatment of MSSA infections

Adverse Effects

Adverse Effects

  • Allergy (immediate or delayed)

  • Cytopenias

  • Eosinophilia

  • Interstitial nephritis

  • Abnormal liver enzymes

  • Phlebitis at injection site in a peripheral vein

Major Interactions

Major Interactions

Can increase methotrexate levels.

Decrease mycophenolate levels.

Coverage

NLPDP Status

OPEN BENEFIT (PO)
No prescribing restrictions

Additional Information

Additional Information

IV Administration
Dilute in 100 mL D5W or NS and administer over 30-60 min.

EH Prescribing Restrictions
None

Community IV Formulary (Metro Area)
YES

Capsules can be opened and administered via NG route; Liquid also available

Administration on empty stomach increases absorption but increases GI intolerance

Pharmacology

Pharmacology

Antimicrobial class: Antistaphylococcal Penicillin

Pregnancy category: B

Average serum half life: 1 hour

Biliary penetration: Moderate

Lung penetration: Therapeutic

Urine penetration: Therapeutic