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Pathogens
Antimicrobials
Cloxacillin 2g IV Q4H
If patient is already on an appropriate anti-MSSA β-lactam for other indications, this may obviate the need to add cloxacillin
Treat for a minimum of 2 weeks after first negative blood culture if patient has no complicating factors
Evidence of endocarditis or metastatic infection
Presence of prostheses
Persistent fever 72 hours after antibiotic initiation
Persistent S.aureus bacteremia 4 days after appropriate antibiotic initiation
Longer treatment duration is needed for patients who have complicated S.aureus bacteremia to prevent relapse
Monitoring
