Non-Enterobacteriaceae

Organisms

Pseudomonas aeruginosa

Acinetobacter baumannii

BCID-Based De-Escalation Options

Cefepime

Piperacillin/tazobactam

Susceptibility-Based De-Escalation Options IV (Narrowest-Spectrum Susceptible Agent)

Cefepime

Piperacillin/tazobactam

Susceptibility-Based De-Escalation Options PO (For Transitions Of Care)

Ciprofloxacin

Levofloxacin

Notes

Please refer to "Risk of beta-lactam resistant Pseudomonas aeruginosa" for optimal empirical antimicrobial therapy in critically-ill patients with BSI due to P. aeruginosa or A. baumannii

Ampicillin-sulbactam may be an option for definitive therapy of susceptible A. baumannii bloodstream isolates

A. baumannii susceptibility to ampicillin-sulbactam is available upon special request