Spectrum: Local Antimicrobial Stewardship, for Prisma Health-Midlands

Cefepime

C. diff Risk

High

Oral Bioavailability

NA

Approximate Cost

$$

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Adult

2g IV q8-12h

Renal

General Information

Acceptable Uses

Appropriate Use

Antimicrobial Stewardship will review therapies greater than 72 hours.

Common Usage

Common Usage

Broad spectrum antimicrobial with gram positive and gram negative coverage including Pseudomonas.

Used especially nosocomial infections involving resistant organisms

Adverse Effects

Adverse Effects

  • Allergy (immediate & delayed)

  • Positive Coombs

  • Cytopenias

  • Non-convulsive status epilepticus

Pharmacology

Pharmacology

Antimicrobial class: 4th generation Cephalosporin

Pregnancy category: B

Average serum half life: 2 hours

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Therapeutic

Biliary penetration: Moderate