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Guidelines
Pathogens
Antimicrobials
Cefepime 2gm IV Q8-12h*
PLUS
Metronidazole
In patients with suspected intra-abdominal source of infection (anaerobic coverage)
OR
Piperacillin/tazobactam 3.375-4.5gm IV Q6h*
Provides adequate coverage for obligate anaerobes
Penicillin Allergy
Risk Factors for Antimicrobial Resistance
*Higher doses may be used for patient specific factors, such as site of infection (pulmonary, central nervous system, etc.) and/or microorganism MIC
Revise antimicrobial regimen based on identification of microorganism, if needed
Streamline definitive therapy based on antimicrobial susceptibility testing results
Treatment Duration Guidelines
