Staph aureus PNA

Preferred Therapy

Methicillin-susceptible Staph aureus (MSSA)

OR

Cloxacillin 2g IV Q6H

Methicillin-resistant Staph aureus (MRSA)

OR

14 day duration of treatment is recommended

Most of the treatment should be completed with IV therapy with the exception of linezolid for MRSA, which can be used orally due to excellent bioavailability

Blood cultures are recommended to ensure absence of bacteremia

Infectious Diseases consultation is recommended

High vancomycin troughs (15-20mg/L) are recommended for MRSA pneumonia

Oral step down of beta-lactams may be considered in patients who are absolutely clinically stable. Use Cephalexin 500mg PO QID for MSSA