Spectrum: Local Antimicrobial Stewardship, for Island Health

Linezolid

C. diff Risk

Low

Oral Bioavailability

Excellent

Approximate Cost

$190/day

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Adult

600mg PO/IV q12h

General Information

Common Usage

Common Usage

Targeted or empiric therapy for gram positive infections including skin and soft tissue, and pneumonia.

Covers MRSA and VRE.

Drug Monitoring

Drug Monitoring

CBC at least once/week.

Visual testing for therapy >3mo or if symptoms develop on therapy.

Adverse Effects

Adverse Effects

  • Myelosuppression (usually with >2weeks therapy)- reversible

  • Peripheral/optic neuropathy with prolonged courses

  • Serotonin syndrome

  • Rash

  • Elevated liver enzymes

  • Lactic acidosis

Major Interactions

Major Interactions

SSRI and other serotonergics/MAOIs- increased risk of serotonin syndrome.

Rifampin decreases linezolid levels.

Pharmacology

Pharmacology

Antimicrobial class: Oxazolidinone

Pregnancy category: C

Average serum half life: 5.0

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Therapeutic