Spectrum: Local Antimicrobial Stewardship, for Yangon Children's Hospital

<3 Years First-Line

First-Line Treatment

Abacavir (ABC) 8 mg/kg/dose, twice per day (max: 300mg/dose)

For age <16 years or weight <37.5kg

OR

Zidovudine (AZT) 180-240 mg/m²/dose, twice per day (max: 300mg/dose)

Drug doses should be calculated according to body surface area

AND

Lamivudine (3TC) twice per day (max: 150mg/dose)

  • Age <30 days: 2 mg/kg/dose

  • Age >30 days: 4 mg/kg/dose

  • Weight >50kg: 150 mg

AND

Lopinavir/Ritonavir co-formulation (LPV/r) 230-350 mg/m², twice per day (max: 400mg/dose LPV + 100mg/dose RTV)

Drug doses should be calculated according to body surface area

Second-Line Treatment (If Failing First-Line Regimen)

ABC (or TDF) + 3TC (or FTC) + RAL (or EFV)

If AZT + 3TC + LPV/r used as first-line regimen

AZT + 3TC + RAL (or EFV)

If ABC + 3TC + LPV/r used as first-line regimen