Spectrum: Local Antimicrobial Stewardship, for Yangon Children's Hospital

<3 Years Second-Line 2

Second-Line Treatment

Zidovudine (AZT) 180-240 mg/m²/dose, twice per day (max: 300mg/dose)

Drug doses should be calculated according to body surface area

AND

Lamivudine (3TC) twice per day (max: 150mg/dose)

  • Age <30 days: 2 mg/kg/dose

  • Age >30 days: 4 mg/kg/dose

  • Weight >50kg: 150 mg

AND

Raltegravir (RAL) 1.5 mg/kg/dose

  • Preferred second-line regimen

  • Neonates ≥37wks and ≥2kg: OD

  • Infants/children >3kg to <20kg: BD

OR

Efavirenz (EFV) once per day (max: 600mg/dose)

  • Alternate second-line regimen

  • Maintain the failing LPV/r-based regimen and then switch to 2NRTIs + EFV at 3 years of age

  • Liquid: 19.5 mg/kg

  • Capsule/tablet: 15 mg/kg