Spectrum: Local Antimicrobial Stewardship, for Yangon Children's Hospital

Treatment

More than 90% of patients can be managed at home with oral antibiotics, reliable care and close medical follow-up for complications or failure to therapy

Indications for hospitalization and parenteral antibiotics

  • Systemic illness

  • Persistent vomiting

  • Severe diarrhea and abdominal distension

  • Other medical and surgical complications

Supportive measures are important in the management of typhoid fever

Such as:

  • Rehydration

  • Antipyretics

  • Appropriate nutrition

  • Blood transfusion as indicated

Antibiotic Therapy

Uncomplicated Disease

Severe Enteric Fever

Fever of >39°C with abnormal state of consciousness, shock, or complications

Notes

Increasing drug resistance has led to a shift toward the third generation cephalosporins, azithromycin, and fluoroquinolones as empiric therapy for typhoid fever while awaiting the results of antimicrobial susceptibilities

Please consult MPS guidelines for full list of complications, and management of chronic carriers and preventive measures, including immunization