Spectrum: Local Antimicrobial Stewardship, for Yangon Children's Hospital

Treatment

Antimicrobial therapy should be initiated early in the course of the disease leptospirosis is suspected

Specific Treament

Benzylpenicillin 1 L/kg (Max. 20L) IV every 4 hours for 7 days

OR

Parenteral Third-Generation Cephalosporins, for example:

Cefotaxime 50 mg/kg every 6 hours for 7 days

Supportive Care

For Hepatitis

  • Discontinue/avoid potentially hepatotoxic medications (like sedatives)

  • Diet: High calorie, good protein intake, a light diet with fruit drinks and glucose

  • Vitamin supplements

Note

The Jarisch–Herxheimer reaction may occur after initiation of antibiotics